Already in the second decade of the 21st century, the museum crisis is at a stage of confrontation between what is denied and what emerges from new actions. As a result, we are experiencing conflicting situations between hegemony and counter-hegemony, academic knowledge and traditional knowledge, exclusion and inclusion, the built museum and the territorialized museum, old and new conceptions. The lecture will address the importance of experimentation in museum communication in participatory processes, with a view to theoretical and methodological advances in transience. Initially, the research in Museology at USP’s Inter-University Postgraduate Program in Museology will be discussed, followed by an account of experiences of appropriation of the museum by indigenous groups.